Therapeutic Effects of Curcumin against Obesity and Obesity Induced Renal Pathology in Experimental Animal Models

Document Type : Original Research

Authors

1 Zoology Dep., Faculty of Science, Aswan Uni.

2 Zoology Dep. , Faculty of Science, Aswan University, Aswan, Egypt

3 Zoology Dep., Faculty of Sci., Aswan Uni.

4 aswan Regional Blood Transfusion Center

Abstract

Obesity and its associated metabolic disorders are considered a growing global epidemic. Curcumin is used as a flavoring agent and food colorant, this polyphenol has been shown to possess many pharmacological properties. The current study was and designed to assess the protective effect of curcumin extract on HFD-induced obese rats. Thirty male albino rats were used in the current study and divided into five groups; control Diet group (CD), High Fat Diet -group (HFD), High Fat Diet + curcumin (HFDC), Vegetable Diet group (VEG) and Vegetable Diet group + Curcumin (VEGC). Body weight was measured 2 times per week during the experiment period (56 days); specimens from kidneys were taken for histopathological studies. The results showed the body weight of HFD-group was increased while decreased in both HFDC and VEG-group. Moreover, severe histopathological changes of kidney were detected in the HFD-group. We conclude, treatment with curcumin extract was effectively alleviated the obesity and obesity induced renal pathology.

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