Protective effect of curcumin against acetamiprid- induced neurotoxicity in male albino rats

Document Type : Original Research

Authors

1 Zoology department, Faculty of Science, Aswan University, Aswan, Egypt

2 Zoology Dep. , Faculty of Science, Aswan University, Aswan, Egypt

3 Professor of molecular biology, zoology department, faculty of science, Aswan university.

4 Zoology department, Faculty of Science, Aswan University, 81582 Aswan, Egypt

5 Zoology department, Faculty of Science, Aswan University, Aswan, Egypt.

Abstract

Acetamiprid (ACMP) is a widely used neonicotinoid that is frequently favored in pest control. After imidacloprid, it is the most commonly manufactured neonicotinoid. It was established that ACMP exhibits brain toxic impact at sub-lethal doses. Curcumin (Cur) a natural polyphenol has been conveyed to possess neuroprotective activity by reducing oxidative stress. The purpose of this study was to look into the neuroprotective role of curcumin against acetamiprid induced neuro-toxicity. In the current study, seventy adult male albino rats were divided into two main groups 20 days and 40 days each of them subdivided into 5 groups consist of: control, vehicle (DMSO), Cur, ACMP and ACMP +Cur group. The current study found that acetamiprid administration resulted in a significant increase in nitric oxide levels (NO) with histopathological changes in brain hippocampus tissue. Curcumin co-administration with acetamiprid significantly reduced nitric oxide levels and protected against acetamiprid-mediated structural changes in the hippocampal tissue.

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Aswan University Journal of Environmental Studies
Volume 3, Issue 3
October 2022
Pages 303-312

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