Protective Role of Curcumin against Aluminum Induced Cerebral Cortical Toxicity in Rats

Document Type : Original Research

Authors

1 Professor of Neurophysiology, zoology department, faculty of science, Aswan university

2 Zoology Dep. , Faculty of Science, Aswan University, Aswan, Egypt

3 Zoology department, Faculty of Science, Aswan University, 81582 Aswan, Egypt

Abstract

Aluminum (Al) is one of the most poisonous metallic elements commonly used. Aluminum is the third most common element and the most common metal on the earth's surface, after oxygen and silicon. Aluminum is one of the most neurotoxic metals which cause oxidative damage. Medicinal plants have been used to treat various pathologies, and bioactive substances are now extracted from plants in therapeutic science. Curcumin (Cur) is a beneficial antioxidant and neuroprotective agent. The goal of this study was to see if curcumin could protect the brain against aluminium toxicity. Seventy adult male albino rats were used in the present study and divided into two main groups 20 days and 40 days each main group subdivided into 5 groups includes: control, vehicle (DMSO), Cur, Al and Al+Cur group. Administration lasted for 20 and 40 days. Nitric oxide (NO) level was estimated and specimens from brain cortex were taken for histopathological studies. The results showed that Aluminum administration exhibited a marked increase in nitric oxide levels and histopathological alterations. Overall, curcumin attenuated the elevation in NO levels and the morphological disturbances caused by aluminum.

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Aswan University Journal of Environmental Studies
Volume 3, Issue 2
June 2022
Pages 235-248

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